The fact that bacteria can be a potential agent for causing infectious disease came from the study on Anthrax, a serious disease of domestic as well as wild animals, which can be transmissible to humans. From 1850 - 1865 many researchers identified a rod shaped bacteria in enormous amount in the blood stream of infected animals i.e. animals suffering from anthrax. One of them was C. J. Davaine, who showed that the rods are invariably present in diseased animals but undetectable in healthy ones and also the disease can be transmitted to healthy animals by introducing the blood containing the rods shaped elements (bacteria).
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